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강현욱

Kang, Hyun-Wook
3D Biofabrication Lab.
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Application of microstereolithography in the development of three-dimensional cartilage regeneration scaffolds

Alternative Title
Application of microstereolithography in the development of three-dimensional cartilage regeneration scaffolds
Author(s)
Lee, Seung-JaeKang, Hyun-WookPark, Jung KyuRhie, Jong-WonHahn, Sei KwangCho, Dong-Woo
Issued Date
2008-04
DOI
10.1007/s10544-007-9129-4
URI
https://scholarworks.unist.ac.kr/handle/201301/13345
Fulltext
http://link.springer.com/article/10.1007%2Fs10544-007-9129-4
Citation
BIOMEDICAL MICRODEVICES, v.10, no.2, pp.233 - 241
Abstract
Conventional methods for fabricating three-dimensional (3-D) tissue engineering scaffolds have substantial limitations. In this paper, we present a method for applying microstereolithography in the construction of 3-D cartilage scaffolds. The system provides the ability to fabricate scaffolds having a pre-designed internal structure, such as pore size and porosity, by stacking photopolymerized materials. To control scaffold structure, CAD/CAM technology was used to generate a scaffold pattern algorithm. Since tissue scaffolds must be constructed using a biocompatible, biodegradable material, scaffolds were synthesized using liquid photocurable TMC/TMP, followed by acrylation at the terminal ends, and photocured under UV light irradiation. The solidification properties of the TMC/TMP polymer were also assessed. To assess scaffold functionality, chondrocytes were seeded on two types of 3-D scaffold and characterized for cell adhesion. Results indicate that scaffold geometry plays a critical role in chondrocyte adhesion, ultimately affecting the tissue regeneration utility of the scaffolds. These 3-D scaffolds could eventually lead to optimally designed constructs for the regeneration of various tissues, such as cartilage and bone
Publisher
SPRINGER
ISSN
1387-2176
Keyword (Author)
microstereolithographyscaffoldchondrocyteCAD/CAM
Keyword
CARBONATE-BASED PREPOLYMERSMICRO-STEREOLITHOGRAPHYDESIGNFABRICATIONCONSTRUCTSTISSUES

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