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Lee, Semin
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Comparative interactomics analysis of protein family interaction networks using PSIMAP (protein structural interactome map)

Alternative Title
Comparative interactomics analysis of protein family interaction networks using PSIMAP (protein structural interactome map)
Author(s)
Park, DaeuiLee, SeminBolser, DanSchroeder, MichaelLappe, MichaelOh, DonghoonBhak, Jong Hwa
Issued Date
2005-08
DOI
10.1093/bioinformatics/bti512
URI
https://scholarworks.unist.ac.kr/handle/201301/13201
Fulltext
http://bioinformatics.oxfordjournals.org/content/21/15/3234
Citation
BIOINFORMATICS, v.21, no.15, pp.3234 - 3240
Abstract
Motivation: Many genomes have been completely sequenced. However, detecting and analyzing their protein-protein interactions by experimental methods such as co-immunoprecipitation, tandem affinity purification and Y2H is not as fast as genome sequencing. Therefore, a computational prediction method based on the known protein structural interactions will be useful to analyze large-scale protein-protein interaction rules within and among complete genomes. Results: We confirmed that all the predicted protein family interactomes (the full set of protein family interactions within a proteome) of 146 species are scale-free networks, and they share a small core network comprising 36 protein families related to indispensable cellular functions. We found two fundamental differences among prokaryotic and eukaryotic interactomes: (1) eukarya had significantly more hub families than archaea and bacteria and (2) certain special hub families determined the topology of the eukaryotic interactomes. Our comparative analysis suggests that a very small number of expansive protein families led to the evolution of interactomes and seemed tohave played a key role in species diversification. Contact: jong@kribb.re.kr Supplementary information: http://interactomics.or
Publisher
OXFORD UNIV PRESS
ISSN
1367-4803
Keyword
COMPARATIVE GENOMICSGENE ONTOLOGYDATABASEEVOLUTIONSEQUENCESCLASSIFICATIONEUKARYOTESBACTERIALBIOLOGYYEAST

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