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- Rhee, Hyun-Woo
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Label-free fluorescent real-time monitoring of adenylyl cyclase
- Alternative Title
- Label-free fluorescent real-time monitoring of adenylyl cyclase
- Author(s)
- Rhee, Hyun-Woo, Kim, Kyoung-Shim, Han, Pyung-Lim, Hong, Jong-In
- Issued Date
- 2010-02
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.3, pp.1145 - 1147
- Abstract
- In cellular signaling, adenylyl cyclase plays a key role in the hydrolysis of ATP to cyclic AMP and pyrophosphate. Using a synthetic fluorescent chemosensor (PyDPA) which binds strongly to the pyrophosphate group, we have developed a label-free fluorescent real-time detection system for adenylyl cyclase. This assay would be the first adenylyl cyclase assay based on chemosensing the production of pyrophosphate. (C) 2009 Elsevier Ltd. All rights reserved
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- ISSN
- 0960-894X
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