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Park, Tae Joo
Developmental Morphogenesis Lab
Research Interests
  • Morphogenesis, chondrogenesis, ciliogenesis

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BIX-01294-induced autophagy regulates elongation of primary cilia

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Title
BIX-01294-induced autophagy regulates elongation of primary cilia
Author
Ji Hyun ShinPan Soo KimEun Sung KimSo Jung ParkYoon Kyung JoJung Jin HwangPark, Tae JooJong Wook ChangJin-Ho SeoDong-Hyung Cho
Keywords
BIX-01294; Autophagy; Cilia; Ciliogenesis; ATG6
Issue Date
201505
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.460, no.2, pp.428 - 433
Abstract
Previously, we showed that BIX-01294 treatment strongly activates autophagy. Although, the interplay between autophagy and ciliogenesis has been suggested, the role of autophagy in ciliogenesis is controversial and largely unknown. In this study, we investigated the effects of autophagy induced by BIX-01294 on the formation of primary cilia in human retinal pigmented epithelial (RPE) cells. Treatment of RPE cells with BIX-01294 caused strong elongation of the primary cilium and increased the number of ciliated cells, as well as autophagy activation. The elongated cilia in serum starved cultured cells were gradually decreased by re-feeding the cells with normal growth medium. However, the disassembly of cilia was blocked in the BIX-01294-treated cells. In addition, both genetic and chemical inhibition of autophagy suppressed BIX-01294-mediated ciliogenesis in RPE cells. Taken together, these results suggest that autophagy induced by BIX-01294 positively regulates the elongation of primary cilium. (C) 2015 Elsevier Inc. All rights reserved.
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DOI
http://dx.doi.org/10.1016/j.bbrc.2015.03.050
ISSN
0006-291X
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