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Suh, Pann-Ghill
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Identification of novel phosphatidic acid-binding proteins in the rat brain

Author(s)
Park, ChiHuKang, Du-SeockShin, Geon-HoonSeo, Jeong KonKim, HyeinSuh, Pann-GhillBae, Chang-DaeShin, Joo-Ho
Issued Date
2015-05
DOI
10.1016/j.neulet.2015.04.012
URI
https://scholarworks.unist.ac.kr/handle/201301/11543
Fulltext
http://www.sciencedirect.com/science/article/pii/S0304394015002852#
Citation
NEUROSCIENCE LETTERS, v.595, pp.108 - 113
Abstract
Phosphatidic acid (PA) is an abundant negatively-charged phospholipid and has long been considered to be an important signaling molecule in diverse cellular events. Thus, the identification of proteins that specifically interact with PA is of considerable interest to understand the regulatory roles of PA. Herein, lipid-affinity purification and mass spectrometric analysis reveals 43 proteins, 19 known and 24 novel, as PA-binding proteins. A lipid-protein overlay assay confirmed that GDI1, PACSIN1, and DPYSL2 interact with not only with PA but also with other phospholipids. These results might be helpful for deciphering the functional effect of PA in the brain. © 2015 Elsevier Ireland Ltd
Publisher
ELSEVIER IRELAND LTD
ISSN
0304-3940
Keyword (Author)
BrainLC-MS/MSLipid-protein interactionPhosphatidic acid

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