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Bhak, Jong
The Genomics Institute of UNIST (TGI)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

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HEpD: A database describing epigenetic differences between Thoroughbred and Jeju horses

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Title
HEpD: A database describing epigenetic differences between Thoroughbred and Jeju horses
Author
Gim, Jeong-AnLee, SugiKim, Dae-SooJeong, Kwang-SeukHong, Chang PyoBae, Jin-HanMoon, Jae-WooChoi, Yong-SeokCho, Byung-WookCho, Hwan-GueBhak, Jong HwaKim, Heui-Soo
Keywords
Differentially methylated region; DNA methylation; Jeju horse; MeDIP-Seq; Thoroughbred horse
Issue Date
201504
Publisher
ELSEVIER SCIENCE BV
Citation
GENE, v.560, no.1, pp.83 - 88
Abstract
With the advent of next-generation sequencing technology, genome-wide maps of DNA methylation are now available. The Thoroughbred horse is bred for racing, while the Jeju horse is a traditional Korean horse bred for racing or food. The methylation profiles of equine organs may provide genomic clues underlying their athletic traits. We have developed a database to elucidate genome-wide DNA methylation patterns of the cerebrum, lung, heart, and skeletal muscle from Thoroughbred and Jeju horses. Using MeDIP-Seq, our database provides information regarding significantly enriched methylated regions beyond a threshold, methylation density of a specific region, and differentially methylated regions (DMRs) for tissues from two equine breeds. It provided methylation patterns at 784 gene regions in the equine genome. This database can potentially help researchers identify DMRs in the tissues of these horse species and investigate the differences between the Thoroughbred and Jeju horse breeds.
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DOI
http://dx.doi.org/10.1016/j.gene.2015.01.047
ISSN
0378-1119
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