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A novel TRAP1 inhibitor, UB-010 potently inactivates the mitochondrial chaperoneby interacting with the client binding site.

Yoon, Nam Gu , Hu, Sung , Kim. So-Yeon , Lee, Changwook , Kang, Byoung Heon

Conference Paper Issue Date2020-10-08 View4

Chemical approaches to development of mitochondrial-targeted Hsp90 inhibitor as anti-cancer drug: Mechanism and conformational change of mitochondrial Hsp90

Hu, Sung , Yoon, Nam gu , Jung, Hyun suck , Han, In cheol , Kang, Byoung Heon

Conference Paper Issue Date2017-05-18 View3

Chemical approaches to development of mitochondrial-targeted Hsp90 inhibitor as anti-cancer therapeutics: Mechanism and conformational change of mitochondrial Hsp90

Hu, Sung , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2017-04-03 View2

Development of mitochondria-targeted Hsp90 inhibitor as a anti-cancer drug

Park, Hye-Jyung , Ko, Eunhwa , Lee, Gemwoo , Lee, Ji-Eun , Lee, Sang Kwang , Jeong, Hanbin , Lee, An-Jung , Im, Jing Young , Hu, Sung , Kim, Seong Heon , et al

Conference Paper Issue Date2016-11-25 View3

Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug File

Hu, Sung , Ferraro, Mariarosaria , Thomas, Ajesh P. , Chung, Jeong Min , Yoon, Nam Gu , Seol, Ji-Hoon , Kim, Sangpil , Kim, Han-Ul , An, Mi Young , Ok, Haewon , et al

Article Issue Date2020-03 View3

Mitochondria target therapy through inhibition TRAP1-IDH2 to treat relapse/refractory AML

Hu, Sung , Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2022-08-26 View4

Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site File

Yoon, Nam Gu , Lee, Hakbong , Kim, So-Yeon , Hu, Sung , Kim, Darong , Yang, Sujae , Hong, Ki Bum , Lee, Ji Hoon , Kang, Soosung , Kim, Byung-Gyu , et al

Article Issue Date2021-12 View24

Novel TRAP1 inhibitor targeting the allosteric drug binding site showed improved anti-cancer activity

Hu, Sung , Yoon, Namgu , Kang, Byoung Heon

Conference Paper Issue Date2019-06-19 View0

Overcoming Chemo-resistance through TRAP1 Inhibition Targeting High Mitochondrial Activity in Relapse/Refractory Acute Myeloid Leukemia

Hu, Sung , Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2022-09-29 View4

Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors File

Park, Hye-Kyung , Jeong, Hanbin , Ko, Eunhwa , Lee, Geumwoo , Lee, Ji-Eun , Lee, Sang Kwang , Lee, An-Jung , Im, Jin Young , Hu, Sung , Kim, Seong Heon , et al

Article Issue Date2017-09 View10

Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors

Park, Hye-Kyung , Jeong, Hanbin , Ko, Eunhwa , Lee, Geunwoo , Lee, Ji-Eun , Lee, Sang Kwang , Lee, An-Jung , Lee, Jin Young , Hu, Sung , Kin, Seong Heon , et al

Conference Paper Issue Date2018-06-28 View7

Treatment Chemo-resistant Acute Myeloid Leukemia by Targeting Mitochondrial Activity

Hu, Sung , Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2023-02-22 View4

Treatment relapse/refractory acute myeloid leukemia through mitochondria target therapy

Hu, Sung , Park, Hye-kyung , Park, Suyeon , Kang, Byoung Heon

Conference Paper Issue Date2023-09-21 View1

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 File File

Park, Hye-Kyung , Yoon, Nam Gu , Lee, Ji-Eun , Hu, Sung , Yoon, Sora , Kim, So Yeon , Hong, Jun-Hee , Nam, Dougu , Chae, Young Chan , Park, Jong Bae , et al

Article Issue Date2020-01 View12

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